Cytogenetic and molecular abnormalities in chronic myelomonocytic leukemia
نویسندگان
چکیده
منابع مشابه
Cytogenetic and molecular abnormalities in chronic myelomonocytic leukemia.
Chronic myelomonocytic leukemia (CMML) is a clonal stem cell disorder associated with peripheral blood monocytosis and an inherent tendency to transform to acute myeloid leukemia. CMML has overlapping features of myelodysplastic syndromes and myeloproliferative neoplasms. Clonal cytogenetic changes are seen in ~30%, whereas gene mutations are seen in >90% of patients. Common cytogenetic abnorma...
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BACKGROUND The prognostic value of cytogenetic findings in chronic myelomonocytic leukemia is unclear. Our purpose was to evaluate the independent prognostic impact of cytogenetic abnormalities in a large series of patients with chronic myelomonocytic leukemia included in the database of the Spanish Registry of Myelodysplastic Syndromes. DESIGN AND METHODS We studied 414 patients with chronic...
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In patients with chronic myelomonocytic leukemia (CMML), age>65 years is an adverse prognostic factor. Our objective in the current study was to examine risk factors for survival and treatment outcome in 261 'young' adults with CMML, as defined by age ⩽65 years. In multivariable analysis, lower HB (P=0.01), higher circulating blast % (P=0.002), ASXL1 (P=0.0007) and SRSF2 mutations (P=0.008) and...
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In the 90’s, only approximately 50% of chronic lymphocytic leukemia (CLL) could be shown to carry a chromosome defect, a figure reflecting inadequate cell division. The introduction of FISH allowed for the detection of chromosome aberrations in 80% of the cases and every patient could be included in a specific group according to a hierarchical cytogenetic classification as follows: 17p> 11q> +1...
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Chronic neutrophilic leukemia (CNL) and atypical chronic myeloid leukemia (aCML) are rare entities grouped into the World Health Organisation (WHO) categories myeloproliferative and myelodysplastic/myeloproliferative neoplasms (MPN and MDS/MPN overlap), respectively. According to the WHO 2008 classification, both entities are characterized by leukocytosis and a hypercellular bone marrow, predom...
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ژورنال
عنوان ژورنال: Blood Cancer Journal
سال: 2016
ISSN: 2044-5385
DOI: 10.1038/bcj.2016.5